Effects of the aqueous extract of Epimedii Herba on the induction of oral tolerance in mice.
نویسندگان
چکیده
We investigated the effects of the aqueous extract of Epimedii Herba (AEEH) on the induction of oral tolerance. Oral tolerance was induced in mice by giving an oral administration of 20 mg ovalbumin (OVA) 7 d before immunization with the antigen. AEEH at 40 mg/kg was given orally daily for 6 d from 24 h after the feeding of OVA. The results showed that oral administration of OVA greatly suppressed total serum and antigen-specific immunoglobulin (Ig) levels, phagocytic activity and delayed-type hypersensitivity (DTH) reaction to the antigen. The suppression of these immune responses to OVA by the oral antigen was associated with a marked reduction of the production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) from spleen cells. However, AEEH treatment significantly blocked the suppression of total serum and antigen-specific IgG2a antibodies, phagocytic activity and DTH response by the oral OVA. The suppression of IFN-y production by the oral antigen was also greatly decreased by AEEH treatment. Therefore, AEEH appears to be effective in preventing the induction of oral tolerance to OVA.
منابع مشابه
Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice
Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. Howeve...
متن کاملOral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms
Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...
متن کاملThe effect of crude aqueous extract of the Allium sativum on spermatogenesis in balb/C mice
Objective: Among herbal medicine, Allium sativum (garlic) has historically been used widely for the treatment of many disease such as hypertension, diabetes, tuberculosis, leprosy, constipation, parasitic infection, food poisoning, emmenagogue, abortion induction and many other disease. However, data about the particular effects of garlic such as activator of spermatogenesis has not been consid...
متن کاملEffects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice
Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. Howeve...
متن کاملP-80: The Effects of Rosa Damascene Aqueous Extract on Reproductive System of Female Mice Following Formaldehyde Treatment
Background Formaldehyde is a chemical precursor, flammable and colorless which is widely used in different industries. Previous studies, have reported that Formaldehyde has destructive effects on reproductive system of female mice. In the present study we aimed at evaluating the protective effects of Rosa damascene on the toxic effects of Formaldehyde on sex hormones, ovary parameters and folli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biological & pharmaceutical bulletin
دوره 25 8 شماره
صفحات -
تاریخ انتشار 2002